|Disease:||Systemic Lupus Erythematosus (SLE)|
|Reference Range:||Negative: <1:40|
|Units:||Titer & ANA pattern reported on all positives.|
|Note:||Positive samples at a 1:40 screening dilution are titered to an endpoint at an additional charge.|
|Schedule / Turnaround Time:||Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt.|
Specimen need not be refrigerated or frozen. Collect 2-3 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into white tube provided with Immco Diagnostics’ collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.
Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8˚C) up to five days and frozen (-20˚C or lower) up to one year.
Antibodies to PCNA are found in approximately 2-10% of systemic lupus erythematosus patients, most of whom have diffuse proliferative glomerulonephritis. They do not occur in patients with other connective tissue diseases. Antibodies to PCNA are not detectable after immunosuppressive therapy.