|Disease:||• Autoimmune Hearing Loss (SNHL) • Relapsing Polychondritis|
|Reference Range:||Negative: <20 ; Borderline: 20-25 ; Positive: >25|
|Schedule / Turnaround Time:||Assay performed once weekly. Report availability is within one week from the time of specimen receipt.|
Specimen need not be refrigerated or frozen. Collect 2-3 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into white tube provided with Immco Diagnostics’ collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.
Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8˚C) up to five days and frozen (-20˚C or lower) up to one year.
Collagen II antibodies occur in 22% of patients with sensory neural hearing loss, 30% of patients with sudden deafness and 67% of patients with Meniere’s disease. Collagen II antibodies also occur in patients with relapsing polychondritis and in patients with rheumatoid arthritis.