| Category: |
Gastroenterology & Hepatology |
|---|---|
| Test Code: | 214 |
| Disease: | • Pernicious Anemia • Inflammatory Bowel Disease (IBD) |
| Methodology: | Indirect Immunofluorescence |
| Substrate: | Mouse Kidney/Stomach/Liver |
| Reference Range: | Negative: <1:10 |
| Units: | Titer |
| Note: | Positive samples at a 1:10 screening dilution are titered to an endpoint at an additional charge. |
| CPT Code: | 86255 |
| Schedule / Turnaround Time: | Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt. |
| Specimen Requirements: |
Specimen need not be refrigerated or frozen. Collect 2-3 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into white tube provided with Immco Diagnostics’ collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection. |
| Sample Stability: |
Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8˚C) up to five days and frozen (-20˚C or lower) up to one year. |
| Relevance: |
AGPA are commonly associated with pernicious anemia and chronic atrophic gastritis where they occur in about 90% and 50% of cases, respectively. Although healthy individuals may have gastric parietal cell antibodies, this finding may reflect asymptomatic atrophic gastritis. Negative findings for gastric parietal cell antibodies provide strong evidence for excluding pernicious anemia. |