Rubella specific IgM antibodies become detectable a few days after the onset of symptoms and reach peak levels at 7 – 10 days. The IgM antibodies persist but rapidly diminish in concentration over the next 4 – 5 weeks. Production of IgG increases rapidly for the next 7 to 21 days, then levels off or even decreases in strength. IgG antibodies remain present and protective indefinitely.
Infection during pregnancy, particularly the first trimester, can result in fetal death or severe anatomical deformity and mental retardation. Therefore, early detection of Rubella infection is extremely important.
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